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irinotecan- and cisplatin-containing nanoparticles

Based on

1 Patents
2014 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

PLGA-mPEG5K

Type Polymer
Formula
Role raw materials
2

dual drug mixture

Type Complex Compound
Formula
Role loaded material

Properties

Applications

Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
human prostatic carcinoma PSMA-overexpressing LNCaP cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
  1. EdCKAdjP51OCM68VqUQtVnKBOON
Product

irinotecan- and cisplatin-containing nanoparticles

Diameter: ~ 39 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
  1. AnFTBgpT6dt44uSUHnJDMPfElKg
Product

irinotecan- and cisplatin-containing nanoparticles

Diameter: ~ 40 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
  1. bI07Dliro42hoO35AJEVKEF1Czg
Product

irinotecan- and cisplatin-containing nanoparticles

Diameter: ~ 40 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
  1. BUDIxnDwjSBmcKlfXzY7ZA00Fx3
Product

irinotecan- and cisplatin-containing nanoparticles

Diameter: ~ 40 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • PLA-succinic acid-conjugated irinotecan
  • PLA-succinic acid-conjugated cisplatin
  • PLGA-mPEG5K
  1. mFDshMi4QMvmh4gw9Nd3UTzbDi3
Product

irinotecan- and cisplatin-containing nanoparticles

Diameter: ~ 50 nm

Medium/Support: none

References

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