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F1 methotrexate-loaded PEGylated DSPC/cholesterol liposomes

Based on

1 Articles
2012 Most recent source

Composition

1

phosphate-buffered saline

PBS
Type Complex Compound
Formula
Role core
2

methotrexate

abitrexate folex MTX
Type Single Compound
Formula C20H22N8O5
Role loaded material
3

[(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate

non-deuterated 1,2-distearoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycerol-3-phosphatidylcholine 1,2-distearoyl-sn-glycero-3-phosphatidylcholine 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine L-α 1,2-distearoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycero-3-phosphorylcholine hydrogenated soy sn-glycero-3-phosphocholine 1,2-dipalmitoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycero-3-phosphocholine 1,2-Distearoyl-sn-glycero-3-phosphocholine hydrogenated soybean phosphatidylcholine hydrogenated soy L-α-phosphatidylcholine distearoyl-sn-glycero-3-phosphocholine hydrogenated soya phosphatidylcholine hydrogenated soy phosphatidylcholine Hydrogenated soy phosphatidylcholine hydrogenated L-α-phosphatidylcholine distearyl-L-α-phosphatidylcholine distearoyl phosphatidylcholine distearyl phosphatidyl choline distearoylphosphatidylcholine L-α-phosphatidylcholine egg PC hDSPC HSPC DSPC DSCP
Type Single Compound
Formula C44H88NO8P
Role layer
4

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- [methoxy(polyethylene glycol)-2000]

DSPE-MPEG 2000
Type Polymer
Formula
Role layer
5

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
male Wistar-Lewis rat with arthritis

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- [methoxy(polyethylene glycol)-2000]
  1. 1IvEDCkes0jViLTlue7OeeYDnIKQcPs72llzrct18z3LIFs3Fp1
Product

F1 methotrexate-loaded PEGylated DSPC/cholesterol liposomes

Size: ~ 210 nm

Medium: phosphate-buffered saline

Support: none

References

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