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targeted polycation-DNA complex liposomes

Based on

1 Articles
2013 Most recent source

Composition

1

water

Type Single Compound
Formula H2O
Role core
2

ct-DNA/siRNA/protamine sulfate salt mixture

Type Complex Compound
Formula
Role loaded material
3

N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium

(N-[1-(2, 3-dioleoyloxy)propyl]-N,N,N-trimethylammoniumsalt) 1,2-di(9Z-octadecenoyloxy)-3-trimethylammonium-propane N-(1-(2,3-dioleoyloxy)propyl)-N,N,N-trimethylammonium N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium 1,2-di-(9Z-octadecenoyl)-3-trimethylammonium-propane 1,2-dioleoyloxy-3-trimethylammonium-propane 1,2-dioleoyl-3-(trimethylammonium)propane 1,2-dioleoyl-3-trimethyl-ammonium-propane 1,2-dioleoyl-3-trimethylammonium propane 1,2-dioleoyl-3-trimethylammonium-propane 1,2-dioleoyl-3-trimethylammonium-propan 1,2-dioleoyl-3-trimethylammoniumpropane DOTAP
Type Single Compound
Formula C42H80NO4
Role layer
4

cholesterol

Type Single Compound
Formula C27H46O
Role loaded material
5

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein)

Type Single Compound
Formula C62H92NO13P
Role loaded material
6

thiolated 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000]

thiolated DSPE-PEG-Mal
Type Polymer
Formula
Role graft
7

anti-EGFR Fab'

Type Biomolecule
Formula
Role graft

Properties

General physical and chemical properties

Property Value Source
stability in serum

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Applications

Area Application Source
drug delivery

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Characterization

Method Source
dynamic light scattering

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Biological effects

Biological system Test details Source
human hepatocellular carcinoma SMMC-7721 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • 2-iminothiolane hydrochloride
  • anti-EGFR Fab'
Product

targeted polycation-DNA complex liposomes

References

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