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docetaxel-loaded poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles

Based on

6 Articles
2017 Most recent source

Composition

1

PLA-TPGS/TPGS-COOH mixture

Type Complex Compound
Formula
Role carriers
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human breast adenocarcinoma MCF-7 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • folic acid-polyethylene glycol-poly(lactic-co-glycolic acid)
  • TPGS-PLGA
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Product

docetaxel-loaded poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles

Size: 80 - 90 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Product

docetaxel-loaded poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles

Hydrodynamic diameter: 178.81 - 185.25 nm

Size: ~ 180 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
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Product

docetaxel-loaded poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles

Hydrodynamic diameter: 375.0 - 394.6 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • d-α-tocopheryl polyethylene glycol 1000 succinate-glutaric acid
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactic acid)-d-α-tocopheryl polyethylene glycol 1000 succinate
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Product

docetaxel-loaded poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles

Size: ~ 180 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate
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Product

docetaxel-loaded poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles

Hydrodynamic diameter: 270.6 - 279.6 nm

Medium: water

Support: none

References

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