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docetaxel-loaded poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles

Based on

6 Articles
2017 Most recent source

Composition

1

FA-PEG-b-PLGA/TPGS-PLGA

Type Complex Compound
Formula
Role carriers
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human breast adenocarcinoma MCF-7 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • P(LA-co-TMCC)-g-PEG,TBP
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • P(LA-co-TMCC)-g-PEG-furan
  1. F54
  2. koFqbp0f1UKd7
  3. Xjbf
Product

docetaxel-loaded poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000]
  1. DdINYzBjVK
Product

docetaxel-loaded poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles

Size: not specified

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • folate-conjugated 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000]
  1. cu1RhLlnS3
Product

docetaxel-loaded poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles

Size: not specified

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  • folic acid-polyethylene glycol-poly(lactic-co-glycolic acid)
  • TPGS-PLGA
  1. bvs4NwHcrywvZD58
  2. 8zBECUDGe
  3. vx6K9zL9Ek
Product

docetaxel-loaded poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles

Size: 80 - 90 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
Product

docetaxel-loaded poly(lactide)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles

Size: 100.6 - 107.2 nm

Medium: phosphate buffer solution

Support: none

References

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