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5-fluorouracil-loaded poly(ε-caprolactone) nanoparticles

Based on

1 Articles
2012 Most recent source

Composition

1

polycaprolactone

PCL
Type Polymer
Formula
Role core
2

poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)

Pluronic® F-68
Type Polymer
Formula
Role layer
3

5-fluoro-2,4(1H,3H)pyrimidinedione

5-Fluorouracil 5-fluorouracil fluorouracil Adrucil® Efudex® adrucil efudex 5-FU 5-Fu 5FU
Type Single Compound
Formula C4H3FN2O2
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human colon adenocarcinoma SW480 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • polycaprolactone
  1. rVM6FlgXVVH9KfdXpoRh5Vp3
Product

5-fluorouracil-loaded poly(ε-caprolactone) nanoparticles

Size: not specified

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • polycaprolactone
  1. W3kgjVCVjtNYTU8qOULFzpkT
Product

5-fluorouracil-loaded poly(ε-caprolactone) nanoparticles

Size: 125 - 175 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • polycaprolactone
  1. evDTkkTg65NzsXyLjigJtR4o
Product

5-fluorouracil-loaded poly(ε-caprolactone) nanoparticles

Size: not specified

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • polycaprolactone
  1. mNEshSw7yJOyRdvSiMYLXwXE
Product

5-fluorouracil-loaded poly(ε-caprolactone) nanoparticles

Size: 100 - 140 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • polycaprolactone
  1. 9Imx0voMerHXLjkwHsfSCywM
Product

5-fluorouracil-loaded poly(ε-caprolactone) nanoparticles

Size: 110 - 160 nm

Medium: water

Support: none

References

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