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ritonavir-loaded Poloxamer 188/N-(carbonyl-methoxypolyethyleneglycol 2000)-1,2 sn-glycero-3-phosphoethanolamine nanoparticles

Based on

1 Articles
2012 Most recent source

Composition

1

(5S,8S,10S,11S)-10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-2,4,7,12-tetraazatridecan-13-oic acid 5-thiazolyl-methyl ester

ritonavir RTV
Type Single Compound
Formula C37H48N6O5S2
Role core
2

Poloxamer 188

P188
Type Polymer
Formula
Role layer
3

N-(carbonyl-methoxypolyethyleneglycol 2000)-1,2 sn-glycero-3-phosphoethanolamine

mPEG2000-DSPE
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
HBMEC human brain microvascular endothelial cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • N-(carbonyl-methoxypolyethyleneglycol 2000)-1,2 sn-glycero-3-phosphoethanolamine
  • aqueous solution
  • Poloxamer 188
See all (4)
Product

ritonavir-loaded Poloxamer 188/N-(carbonyl-methoxypolyethyleneglycol 2000)-1,2 sn-glycero-3-phosphoethanolamine nanoparticles

Size: 443 nm

Medium: aqueous solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • N-(carbonyl-methoxypolyethyleneglycol 2000)-1,2 sn-glycero-3-phosphoethanolamine
  • Poloxamer 188
  1. 2Cmx6ePCS0um7NgCs6TRjS
Product

ritonavir-loaded Poloxamer 188/N-(carbonyl-methoxypolyethyleneglycol 2000)-1,2 sn-glycero-3-phosphoethanolamine nanoparticles

Size: 613 nm

Medium: HEPES buffer

Support: none

References

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