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paclitaxel-loaded poly(2-hydroxyethyl methacrylate)-g-poly(lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer nanoparticles

Based on

1 Articles
2012 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

Paclitaxel

Plaxicel Abraxane Paxene Taxol PCL PAC PTX PX
Type Single Compound
Formula C47H51NO14
Role core
2

poly(2-hydroxyethyl methacrylate)-g-poly(lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer

PHEMA-g-(PLA-DPPE) copolymer
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human breast cancer MCF-7 cells

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Preparation

Method 1

Type: Physical formation
Source:
Product

paclitaxel-loaded poly(2-hydroxyethyl methacrylate)-g-poly(lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer nanoparticles

Hydrodynamic diameter: ~ 100 - 900 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(2-hydroxyethyl methacrylate)-g-poly(lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer
  • Paclitaxel
  1. akAnJlmiPHOv1UbK5wnkJduvn21Zeq
Product

paclitaxel-loaded poly(2-hydroxyethyl methacrylate)-g-poly(lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer nanoparticles

Hydrodynamic diameter: 293.1 - 298.1 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(2-hydroxyethyl methacrylate)-g-poly(lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer
  • Paclitaxel
  1. DHE2cGQUiqXrYNV85ofhclE2CH9nXr
Product

paclitaxel-loaded poly(2-hydroxyethyl methacrylate)-g-poly(lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer nanoparticles

Hydrodynamic diameter: 247.7 - 252.3 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • poly(2-hydroxyethyl methacrylate)-g-poly(lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer
  • Paclitaxel
  1. zSbAdoEOUsTS4zz1MwDi0oxQcLlbWF
Product

paclitaxel-loaded poly(2-hydroxyethyl methacrylate)-g-poly(lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer nanoparticles

Hydrodynamic diameter: 254.2 - 260.4 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • poly(2-hydroxyethyl methacrylate)-g-poly(lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer
  • Paclitaxel
  1. reHR7DyRusvPDQmtjPo9lKKKTQHWQq
Product

paclitaxel-loaded poly(2-hydroxyethyl methacrylate)-g-poly(lactide)-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer nanoparticles

Size: 120 - 225 nm

Medium/Support: none

References

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