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dimethyldidodecylammonium bromide-modified doxorubicin-loaded poly(lactic-co-glycolic acid)/1,2-dipalmitoyl-sn-glycero-3-phosphocholine core/shell particles

Based on

1 Articles
2012 Most recent source

Composition

1

doxorubicin-poly(lactic-co-glycolic acid) conjugate

DOX-PLGA conjugate
Type Polymer
Formula
Role core
2

N-dodecyl-N,N-dimethyldodecan-1-aminium bromide

dodecyl-N,N-dimethyl-1-dodecanaminium bromide didodecyl dimethylammonium bromide didodecyldimethylammonium bromide dimethyldidodecylammonium bromide dilauryldimethylammonium bromide dDDdMABr DDAB DMAB
Type Single Compound
Formula C26H56BrN
Role layer
3

1,2-dipalmitoyl-sn-glycero-phosphatidylcholine

dipalmitoyl phosphatidylcholine dipalmitoylphosphatidylcholine DPPC
Type Single Compound
Formula C40H80NO8P
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
colloidal stability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
Michigan Cancer Foundation-7 (MCF-7) cells

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Preparation

Method 1

Type: Physical formation
Source:
Product

dimethyldidodecylammonium bromide-modified doxorubicin-loaded poly(lactic-co-glycolic acid)/1,2-dipalmitoyl-sn-glycero-3-phosphocholine core/shell particles

Size: 167.8 - 222.2 nm

Thickness: ~ 20 nm

Medium: serum-supplemented RPMI 1640 medium

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 1,2-dipalmitoyl-sn-glycero-phosphatidylcholine
  1. yCNTLGAiUa6jY8G6WsCNU
  2. MfhUi
Product

dimethyldidodecylammonium bromide-modified doxorubicin-loaded poly(lactic-co-glycolic acid)/1,2-dipalmitoyl-sn-glycero-3-phosphocholine core/shell particles

Thickness: ~ 20 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • 1,2-dipalmitoyl-sn-glycero-phosphatidylcholine
  1. HFMWGXt9zMpvCz4Qe3c7v
  2. 9yvop
Product

dimethyldidodecylammonium bromide-modified doxorubicin-loaded poly(lactic-co-glycolic acid)/1,2-dipalmitoyl-sn-glycero-3-phosphocholine core/shell particles

Thickness: ~ 20 nm

Medium/Support: none

References

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