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emtansine-loaded star-shaped folate-core polylactide-D-α-tocopheryl polyethylene glycol 1000 succinate copolymer nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

linear folate-polylactide-D-α-tocopheryl polyethylene glycol 1000 succinate copolymer

linear FA-PLA-TPGS copolymer
Type Polymer
Formula
Role carriers
2

mertansine

emtansine DM1
Type Single Compound
Formula C35H48ClN3O10S
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
MCF-7/HER2(ER<sup>+</sup>, HER2-HIGH) human breast adenocarcinoma cell

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • star-shaped core polylactide-D-α-tocopheryl polyethylene glycol 1000 succinate copolymer
  • mertansine
  1. RkHKsEEvcoo9qf6bb
  2. V0S1q60Ns0B2hMdNIVp5uAFMiiUzz
Product

emtansine-loaded star-shaped folate-core polylactide-D-α-tocopheryl polyethylene glycol 1000 succinate copolymer nanoparticles

Size: 119.8 - 127.6 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • star-shaped folate-core polylactide-D-α-tocopheryl polyethylene glycol 1000 succinate copolymer
  • mertansine
  1. L1LRP5Oq1tDMjwX7A
  2. KMACvUVSUccsW0A70fESLx1GAfs8Y
Product

emtansine-loaded star-shaped folate-core polylactide-D-α-tocopheryl polyethylene glycol 1000 succinate copolymer nanoparticles

Size: 123.1 - 130.1 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • linear folate-polylactide-D-α-tocopheryl polyethylene glycol 1000 succinate copolymer
  • mertansine
  1. GfWqssDY6OPcHk7mo
  2. MOG2zkhUHNpBDVRw3Lrd32pR96T7w
Product

emtansine-loaded star-shaped folate-core polylactide-D-α-tocopheryl polyethylene glycol 1000 succinate copolymer nanoparticles

Size: not specified

Medium/Support: none

References

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