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itraconazole-loaded Solutol-HS15-stabilized Precirol ATO 5/Transcutol HP lipid carriers

Based on

1 Articles
2014 Most recent source

Composition

1

diethylene glycol monoethyl ether

2-(2-ethoxyethoxy)ethanol Transcutol® HP ethoxydiglycol Transcutol HP Transcutol P Transcutol Carbitol carbitol DEGMEE DGME
Type Single Compound
Formula C6H14O3
Role core
2

1,3-dioctadecanoylglycerol

glyceryl palmitostearate glycerol distearate Precirol ATO 5
Type Single Compound
Formula C39H76O5
Role fillers
3

polyoxyl-15-hydroxystearate

Solutol®-HS15
Type Polymer
Formula
Role layer
4

cis-2-sec-butyl-4-[4-(4-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4- ylmethoxy]phenyl}piperazin-1-yl)phenyl]-2,4-dihydro-1,2,4-triazol-3-one

itraconazole
Type Single Compound
Formula C35H38Cl2N8O4
Role loaded material

Properties

General physical and chemical properties

Property Value Source
Zeta potential

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Applications

Area Application Source
drug delivery

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Characterization

Biological effects

Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cis-2-sec-butyl-4-[4-(4-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4- ylmethoxy]phenyl}piperazin-1-yl)phenyl]-2,4-dihydro-1,2,4-triazol-3-one
  • diethylene glycol monoethyl ether
  • 1,3-dioctadecanoylglycerol
  1. B9Qc50O
Product

itraconazole-loaded Solutol-HS15-stabilized Precirol ATO 5/Transcutol HP lipid carriers

Method 2

Type: Physical formation
Source:
Starting materials
  • cis-2-sec-butyl-4-[4-(4-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4- ylmethoxy]phenyl}piperazin-1-yl)phenyl]-2,4-dihydro-1,2,4-triazol-3-one
  • diethylene glycol monoethyl ether
  • 1,3-dioctadecanoylglycerol
  1. rb5lMWa
Product

itraconazole-loaded Solutol-HS15-stabilized Precirol ATO 5/Transcutol HP lipid carriers

Method 3

Type: Physical formation
Source:
Starting materials
  • cis-2-sec-butyl-4-[4-(4-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4- ylmethoxy]phenyl}piperazin-1-yl)phenyl]-2,4-dihydro-1,2,4-triazol-3-one
  • diethylene glycol monoethyl ether
  • 1,3-dioctadecanoylglycerol
  1. 9XVIGk3
Product

itraconazole-loaded Solutol-HS15-stabilized Precirol ATO 5/Transcutol HP lipid carriers

Method 4

Type: Physical formation
Source:
Starting materials
  • cis-2-sec-butyl-4-[4-(4-{4-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4- ylmethoxy]phenyl}piperazin-1-yl)phenyl]-2,4-dihydro-1,2,4-triazol-3-one
  • diethylene glycol monoethyl ether
  • 1,3-dioctadecanoylglycerol
  1. 7MSuiuC
Product

itraconazole-loaded Solutol-HS15-stabilized Precirol ATO 5/Transcutol HP lipid carriers

References

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