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daunorubicin-loaded crosslinked poly(ethylene glycol)-b-poly(aspartic acid)-b-poly(D-leucine-co-tyrosine) micelles

Based on

1 Articles
2012 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

daunorubicin

DNR
Type Single Compound
Formula C27H29NO10
Role core
2

N3-PEG12K-b-poly(Asp)10-b-poly(Tyr20-co-D-Leu20)-Ac

Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
Sprague-Dawley rat

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • N3-PEG12K-b-poly(Asp)10-b-poly(Tyr20-co-D-Leu20)-Ac
  • daunorubicin
  1. C5fCQ
  2. v6rJ6draWNi9uSo
  3. hCHE0GRV
  4. WloThuo9BDtw7
Product

daunorubicin-loaded crosslinked poly(ethylene glycol)-b-poly(aspartic acid)-b-poly(D-leucine-co-tyrosine) micelles

Hydrodynamic diameter: 30 nm

Medium: sodium chloride solution

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • N3-PEG12K-b-poly(Asp)10-b-poly(Tyr20-co-D-Leu20)-Ac
  • daunorubicin
  1. NA4gJ
  2. CkmY1ManHlpqS0C
  3. i1CrbPBq
  4. 9makz9rnZXxfU
Product

daunorubicin-loaded crosslinked poly(ethylene glycol)-b-poly(aspartic acid)-b-poly(D-leucine-co-tyrosine) micelles

Size: not specified

Medium/Support: none

References

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