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oil-filled lipid nanoparticles containing docetaxel conjugate

Based on

1 Articles
2011 Most recent source

Composition

1

propane-1,2,3-triyl trioctanoate

1,2,3-trioctanoyl glycerol caprylic acid triglyceride caprylic triglyceride glyceryl tricaprylate Captex® 8000 Miglyol® 808 Captex 8000 miglyol 808 tricaprylin trioctanoin
Type Single Compound
Formula C27H50O6
Role core
2

polyoxyl 20-stearyl ether

Brij 78
Type Polymer
Formula
Role layer
3

D-α-tocopheryl polyethylene glycol succinate

vitamin E TPGS TPGS
Type Polymer
Formula
Role layer
4

2'-stearoyl-docetaxel

C18-DX
Type Single Compound
Formula C61H87NO15
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human prostate cancer DU-145 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
Product

oil-filled lipid nanoparticles containing docetaxel conjugate

Size: not specified

Medium: BALB/c mouse blood plasma

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • polyoxyl 20-stearyl ether
  • propane-1,2,3-triyl trioctanoate
  • D-α-tocopheryl polyethylene glycol succinate
  1. CU3sDs2
Product

oil-filled lipid nanoparticles containing docetaxel conjugate

Size: ~ 200 nm

Medium: aqueous lactose solution

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • propane-1,2,3-triyl trioctanoate
  • polyoxyl 20-stearyl ether
  • D-α-tocopheryl polyethylene glycol succinate
  1. iEY8Qi4
Product

oil-filled lipid nanoparticles containing docetaxel conjugate

Size: not specified

Medium: aqueous lactose solution

Support: none

References

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