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MTX-loaded pH-sensitive fusogenic polymer-modified nanoliposomes

Based on

1 Articles
2014 Most recent source

Composition

1

phosphate buffer solution

PBS
Type Complex Compound
Formula
Role core
2

1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione

1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino) ethylamino]-anthracene-9,10-dione mitoxantrone mitox MTX MTO Mit
Type Single Compound
Formula C22H28N4O6
Role loaded material
3

1,2-dipalmitoyl-sn-glycero-phosphatidylcholine

dipalmitoyl phosphatidylcholine dipalmitoylphosphatidylcholine DPPC
Type Single Compound
Formula C40H80NO8P
Role layer
4

(9Z)-9-Octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester

(9Z)-9-octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine 1,2-dioleoyl-sn-glycero-3-phosphorylethanolamine 1,2-dioctanoyl-sn-glycero-3-phosphoethanolamine 1,2-dioleoyl-sn-glycero- 3-phosphoethanolamine 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine 1,2-dioleoylphosphatidylethanolamine dioleoyl phosphatidylethanolamine dioleoylphosphatidylethanolamine Lipoid PE 18:1/18:1 DOPE
Type Single Compound
Formula C41H78NO8P
Role loaded material
5

poly(monomethyl itaconate)-co-poly[2-(N,N-dimethylamino)ethyl methacrylate]

PMMI-co-PDMAEMA
Type Polymer
Formula
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human breast cancer MCF-7 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(monomethyl itaconate)-co-poly[2-(N,N-dimethylamino)ethyl methacrylate]
  • (9Z)-9-Octadecenoic acid (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
  • 1,2-dipalmitoyl-sn-glycero-phosphatidylcholine
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  2. jHRpvs
Product

MTX-loaded pH-sensitive fusogenic polymer-modified nanoliposomes

Hydrodynamic diameter: 121.3 - 153.9 nm

Medium: aqueous solution

Support: none

References

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