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DDP prodrug-loaded poly(lactic-co-glycolic acid)-lecithin-poly(ethylene glycol) core-shell nanoparticles

Based on

1 Articles
2012 Most recent source

Composition

1

poly(lactic-co-glycolic acid)-lecithin-poly(ethylene glycol) core-shell nanoparticles

PLGA-lecithin-PEG NP
Type Nano Material
Formula
Role carriers
2

c,c,t-[Pt(NH3)2Cl2(O2CCH2CH2CH2CH2CH3)2]

cisplatin prodrug DDP prodrug
Type Single Compound
Formula C12H28Cl2N2O4Pt
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
encapsulation efficiency dependent on drug-PLGA mass ratio

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human breast cancer MCF-7 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • DSPE-PEG-COOH
  • c,c,t-[Pt(NH3)2Cl2(O2CCH2CH2CH2CH2CH3)2]
  • poly(lactic-co-glycolic acid)
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Product

DDP prodrug-loaded poly(lactic-co-glycolic acid)-lecithin-poly(ethylene glycol) core-shell nanoparticles

Hydrodynamic diameter: 110 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • c,c,t-[Pt(NH3)2Cl2(O2CCH2CH2CH2CH2CH3)2]
  • poly(lactic-co-glycolic acid)
  • lecithin
See all (4)
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Product

DDP prodrug-loaded poly(lactic-co-glycolic acid)-lecithin-poly(ethylene glycol) core-shell nanoparticles

Size: not specified

Medium: water

Support: none

References

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