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DDP-loaded poly(lactic-co-glycolic acid)-lecithin-poly(ethylene glycol) core-shell nanoparticles

Based on

1 Articles
2012 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

poly(lactic-co-glycolic acid)-lecithin-poly(ethylene glycol) core-shell nanoparticles

PLGA-lecithin-PEG NP
Type Nano Material
Formula
Role carriers
2

cis-diammineplatinum(II) dichloride

cis-platinum(ll)diamine dichloride cis-diamminedichloroplatinum(II) cis-dichlorodiammineplatinum(II) diammineplatinum(ll) dichloride cis-diamminedichloroplatinum cis-dichlorodiamminoplatinum cis-platinum (II) Pt(NH3)2Cl2 briplatin cisplatin platinol® CDDP CISP CPt
Type Single Compound
Formula PtCl2N2H6
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
encapsulation efficiency dependent on drug-PLGA mass ratio

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human breast cancer MCF-7 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cis-diammineplatinum(II) dichloride
  • DSPE-PEG-COOH
  • poly(lactic-co-glycolic acid)
See all (4)
  1. BFYHPFcuAFk6
  2. kQCTB
  3. Wm0HxyC
  4. gFZt
  5. 7XDpuYTo
Product

DDP-loaded poly(lactic-co-glycolic acid)-lecithin-poly(ethylene glycol) core-shell nanoparticles

Hydrodynamic diameter: 107 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • cis-diammineplatinum(II) dichloride
  • poly(lactic-co-glycolic acid)
  • lecithin
See all (4)
  1. pHLdk77ikMP8
  2. C3bVo
  3. fP7bnsV
  4. JTtl
  5. 204oEgtL
Product

DDP-loaded poly(lactic-co-glycolic acid)-lecithin-poly(ethylene glycol) core-shell nanoparticles

Size: not specified

Medium: water

Support: none

References

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