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methotrexate-glycine-phenylalanine conjugated O,N-carboxymethyl chitosan nanoparticles

Based on

1 Articles
2014 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

methotrexate-glycine-phenylalanine conjugated O,N-carboxymethyl chitosan

O,N-CMCS-Gly-Phe-MTX
Type Biomolecule
Formula
Role raw materials

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on enzyme type

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human myeloma RPMI 8226 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • O-carboxymethylated chitosan
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  2. sKJCbsiw8h3jEwRZ
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Product

methotrexate-glycine-phenylalanine conjugated O,N-carboxymethyl chitosan nanoparticles

Hydrodynamic diameter: 98 - 118 nm

Medium: phosphate buffer solution

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • O-carboxymethylated chitosan
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  2. n3APC0lThy6uCeHt
  3. smi
Product

methotrexate-glycine-phenylalanine conjugated O,N-carboxymethyl chitosan nanoparticles

Hydrodynamic diameter: 90 - 92 nm

Medium: phosphate buffer solution

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • O-carboxymethylated chitosan
  1. TtO72t473cSh0EqjDpKKSyQwxWjNDeE6PG42pd5cH8Dic4GFrKWF6mS22FYysUc87shdJ8dwnmsGVRrSUNCDJnv3Ucg3uzOTpPjV7
  2. YMPeyiESSbb1FFSG
  3. EBT
Product

methotrexate-glycine-phenylalanine conjugated O,N-carboxymethyl chitosan nanoparticles

Hydrodynamic diameter: 114 - 118 nm

Medium: phosphate buffer solution

Support: none

References

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