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clodronate-loaded LyP-1-functionalized poly(lactic-co-glycolic acid) nanoparticles

Based on

1 Articles
2013 Most recent source

Composition

1

aqueous solution

Type Complex Compound
Formula
Role core
2

(dichloro-phosphono-methyl)phosphonic acid disodium salt

sodium clodronate clodronate
Type Single Compound
Formula CH2Cl2Na2O6P2
Role loaded material
3

amine-modified poly(lactic-co-glycolic acid)/PLGA-PEG5000

amine-modified PLGA/PLGA-PEG5000 PLGA-NH2/PLGA-PEG5000
Type Complex Compound
Formula
Role layer
4

sulfo-SMCC moiety

Type Single Compound
Formula -C12H16N2O3S-
Role layer
5

LyP-1 peptide

Type Biomolecule
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
BALB/c mouse with 4T1 mouse breast xenograft tumor

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Preparation

Method 1

Type: Physical formation
Source:
Product

clodronate-loaded LyP-1-functionalized poly(lactic-co-glycolic acid) nanoparticles

Hydrodynamic diameter: 255 - 285 nm

Medium: water

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • (dichloro-phosphono-methyl)phosphonic acid disodium salt
  • PLGA-PEG5000 polymer
  • amine-modified poly(lactic-co-glycolic acid)
See all (4)
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  2. G5lpk2Anzw25i0IPa5XPJNP3YAIUNz
  3. jbEn9Oe0b4
  4. NSKosHQXa1WJpxV305D7Iu7o7u9RkYkjpxT7RXhNuZJS
Product

clodronate-loaded LyP-1-functionalized poly(lactic-co-glycolic acid) nanoparticles

Size: not specified

Medium/Support: none

References

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