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docetaxel-loaded poly(ethylene glycol)-poly(ε-caprolactone) nanoparticles

Based on

1 Articles
2012 Most recent source

Composition

1

polycaprolactone

PCL
Type Polymer
Formula
Role core
2

gelatinase-cleavable peptide

PVGLIG
Type Single Compound
Formula C25H46N6O6
Role layer
3

poly(ethylene glycol)

poly(ethylene oxide) polyethylene glycol polyethylene oxide polyoxyethylene PEO PEG POE
Type Polymer
Formula
Role layer
4

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
docetaxel release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
scanning electron microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
murine hepatic H22 tumor-bearing mice

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Preparation

Method 1

Type: Physical formation
Source:
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  2. 6zwjJcESDNkeHKtpS34R9XNKK
Product

docetaxel-loaded poly(ethylene glycol)-poly(ε-caprolactone) nanoparticles

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • PEG-Pep-PCL nanoparticles
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  1. QaJBnW996Hm6m8FnqKHgpg
  2. voPHAzL
Product

docetaxel-loaded poly(ethylene glycol)-poly(ε-caprolactone) nanoparticles

Diameter: ~ 85.7 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • PEG-Pep-PCL nanoparticles
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  1. dlPjMBNctrZFEaixctaugX
  2. xr8rS2l
Product

docetaxel-loaded poly(ethylene glycol)-poly(ε-caprolactone) nanoparticles

Diameter: ~ 60 nm

Medium/Support: none

References

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