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paclitaxel-loaded poly(lactide)-poly(ethylene glycol) nanoparticles

Based on

3 Articles
2013 Most recent source

Composition

1

Paclitaxel

Plaxicel Abraxane Paxene Taxol PCL PAC PTX PX
Type Single Compound
Formula C47H51NO14
Role core
2

poly(glycolide-co-ε-caprolactone)-b-D-α-tocopheryl PEG 2000 succinate diblock copolymer

poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (PGA-co-PCL)-b-TPGS2k poloxamer 188
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human glioblastoma U-87 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • Paclitaxel
  1. wY0IGuKs5AgvW5vKKMuUKhUD
Product

paclitaxel-loaded poly(lactide)-poly(ethylene glycol) nanoparticles

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • Paclitaxel
  1. ZDkPEerGz5EL1cqbt3H4RXXq
Product

paclitaxel-loaded poly(lactide)-poly(ethylene glycol) nanoparticles

Size: not specified

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(glycolide-co-ε-caprolactone)-b-D-α-tocopheryl PEG 2000 succinate diblock copolymer
  • Paclitaxel
  1. wWY8D1xnybZ8YkilukJBCZWaOS80BueG1uczk
  2. fVUGgRZkbayZwRNOo
  3. SR0pPnLTcH
  4. dpAop
Product

paclitaxel-loaded poly(lactide)-poly(ethylene glycol) nanoparticles

Diameter: 196.8 - 207.4 nm

Hydrodynamic diameter: ~ 70 - ~ 120 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
  1. 39U3qlX5GtNafHAM
Product

paclitaxel-loaded poly(lactide)-poly(ethylene glycol) nanoparticles

Size: 269.0 - 320.8 nm

Medium: water

Support: none

References

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