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c[RGDyK]/Angiopep-2-modified PAMAM-G5

Based on

1 Articles
2012 Most recent source

Composition

1

poly(amidoamine) dendrimer

PAMAM G5 dendrimer PAMAM-G5
Type Polymer
Formula
Role core
2

Mal-PEG2K-NHS

Type Polymer
Formula
Role layer
3

c[RGDyK] peptide

Type Biomolecule
Formula
Role layer
4

cyanine 5.5

Cy5.5
Type Single Compound
Formula C40H46N2O5P1+
Role layer
5

9-(2-carboxyphenyl)-6-(diethylamino)-N,N-diethyl-3H-xanthen-3-iminium chloride

Rhodamine 610 Rhodamine B rhodamine B rhodamine-B Rhodamine rhodamine Rh 610 Rho B Rho-B RhoB Rhod RhB RDB Rho RB
Type Single Compound
Formula C28H31ClN2O3
Role layer
6

poly (N-succinimidyl 3-maleimidopropionate/N-succinimidyl 3-maleimidopropionate/dimethylene oxide/dimethylene oxide/C9H11N2OS2-/C9H11N2OS2-)

Type Polymer
Formula
Role layer
7

cysteine modified Angiopep-2 peptide

Type Biomolecule
Formula
Role layer
8

Gd3+-DOTA

DOTA-Gd
Type Single Compound
Formula GdC16H25N4O8
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
longitudinal magnetic resonance relaxivity

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Applications

Area Application Nanomaterial Variant Source
diagnostics

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
human glioblastoma U87MG cell

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • (2-pyridyldithio)propionic acid N-succinimidyl ester
  • Mal-PEG2K-NH2
  1. 7E27YozEimdJ
  2. TnQBCHYyCzUnlmpnpTGdd
Product

c[RGDyK]/Angiopep-2-modified PAMAM-G5

Hydrodynamic diameter: 15.6 nm

Medium/Support: none

References

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