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poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Based on

1 Patents
2014 Most recent source

Composition

1

acetylated carboxymethylcellulose

CMC-Ac
Type Biomolecule
Formula
Role raw materials
2

poly(ethylene glycol) methyl ether

mPEG-OH
Type Polymer
Formula
Role graft
3

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
EMT-6 tumor-bearing female BALB/c mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. 7PHl7O0L5xIdHxMYHZbXTaNHmkrRe
  2. pcC1fCuiE1OYWxZfdU9f7xIcoExfXGo25Iw2kqWrKHliWi4sY3oIVkSt6kqsCwTYEeKz9R
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 71.8 nm

Medium: water

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. SLpGGCetY6NRKHXhUGfDW1HG9rBEz
  2. TweupnbLlzZKOdoxIGrs6b8igQxV7ngNl3IJDCQ8RdFcSQyuKJIZX7f7VScbKhXDsHpNKJ
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 119 nm

Medium: water

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. X7zMuOyWIreqeuf5Qp5gnBTgOnDma
  2. JktAaIalHF8HJ1iw4G1SvAs10PQmkyBqENoLeNYyhpi31WaXsAQtGJJ9NGrhns5vo0KuL1
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 107.2 nm

Medium: water

Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. PSTr7OjGwq14NtyrSpg7p4aaQk4R3
  2. HA6ecjcjmgkmawYatyh8PreMUjbhkI6Mjifku1GCt3CzfnfbNsiqYFKOpumgxWVSNbXrSq
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 118.4 nm

Medium: water

Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. rxS4fqT8IjrIcdo7bvvBJiaRq9kcn
  2. bfaGSvPmn5wAoemOQdeUaDQNE2UC1CIgFhTN43uXYdDDrSAdc3eKpQh9UpCgLZRQl08ekC
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 49.4 nm

Medium: water

Support: none

References

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