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poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Based on

1 Patents
2014 Most recent source

Composition

1

acetylated carboxymethylcellulose

CMC-Ac
Type Biomolecule
Formula
Role raw materials
2

poly(ethylene glycol) methyl ether

mPEG-OH
Type Polymer
Formula
Role graft
3

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material

Properties

Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
EMT-6 tumor-bearing female BALB/c mouse

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. A4IjD71auvaVfQ7s8Gl1ZTsKSqe0b
  2. FdbgkhbD2V6Ti2yDmui9X5ZnWmm25uu3eIEPv0Qjpxjx6lpL2blevHc7Ofnb0gVXTGonP1
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Size: not specified

Medium: water

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. 2sYD4wwZayyVVeO8Oyj50VaMfF9mP
  2. HGY92zhI2R4gN9bdXkdLveTnWaTojeqWvWZdNr98xX3DthbQnlIBgvCtFh4lL4hrh9tQXZ
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 118.2 nm

Medium: water

Support: none

Method 3

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. sd2cticzDNavfYKrh0uEi7rSYHxVL
  2. sCTHI5EIPZg4DG4wcinuH1jZwaFGq9QPzvwnGK40ZdmtPCX6SPdIaZSJG2vgpUaZ6qM4uM
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 105.4 nm

Medium: water

Support: none

Method 4

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. lj4LyNcBIBca1iClhsq2NcqSNv7UV
  2. RPd3FVr2GozVp9fQcoRqLVpGg3rMRfeZte0mdAEQ5Q991txjl14dG1O8fRf9siPQCJHLTb
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 102.1 nm

Medium: water

Support: none

Method 5

Type: Chemical synthesis
Source:
Starting materials
  • acetylated carboxymethylcellulose
  1. s2D6C0LJZ2uMScNVGse6igufu0RrC
  2. rh2pCWXcaFTomXYtKr8fI4gzy1MZS5Mnikf1aHpsmikpzhY3PkgKi2rkaqY5dohF2oTXhn
Product

poly(ethylene glycol) methyl ether/docetaxel-conjugated acetylated carboxymethylcellulose nanoparticles water suspension

Hydrodynamic diameter: 117.8 nm

Medium: water

Support: none

References

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