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methotrexate-loaded poly(lactic acid)-methacrylic acid copolymeric nanoparticles

Based on

4 Articles
2017 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

poly(lactic acid)-methacrylic acid copolymer

PLA-MAA copolymer
Type Complex Compound
Formula
Role carriers
2

methotrexate

abitrexate folex MTX
Type Single Compound
Formula C20H22N8O5
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
atomic force microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
A-549 human lung adenocarcinoma cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer
  • methotrexate
  1. 3YqJN3XxQEN48U5bB4I
  2. WEyflSCsEgc6jKq1bev
Product

methotrexate-loaded poly(lactic acid)-methacrylic acid copolymeric nanoparticles

Hydrodynamic size: ~ 22 nm

Medium: water

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer
  • methotrexate
  1. LA9CSP4UhtO4zajsL4V
  2. sOmdCnuB05Afiq1JkrT
Product

methotrexate-loaded poly(lactic acid)-methacrylic acid copolymeric nanoparticles

Hydrodynamic size: ~ 26 nm

Medium: water

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(methacrylic acid-co-methyl methacrylate) 1:2
  • poly(lactic acid)
  • methotrexate
  1. WaYW5zfq5faQC
  2. SIDAAmKX7ipLgufxrxnFrwnYL73pXEcaI0z5KfI3Wxc2pIo9
  3. uD3ZN1WE0nUfvR
Product

methotrexate-loaded poly(lactic acid)-methacrylic acid copolymeric nanoparticles

Hydrodynamic diameter: ~ 1012 nm

Medium: water

Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • poly(methacrylic acid-co-methyl methacrylate) 1:2
  • poly(lactic acid)
  • methotrexate
  1. S4wB1E6h89DrU
  2. rOSZo9jyowAtBr8k9VaetiaBVKUeQGiqe02DeUw8mZrC3vVk
  3. 59A55ND5CFg4cU
Product

methotrexate-loaded poly(lactic acid)-methacrylic acid copolymeric nanoparticles

Hydrodynamic diameter: ~ 222.1 nm

Medium: water

Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • poly(methacrylic acid-co-methyl methacrylate) 1:2
  • poly(lactic acid)
  • methotrexate
  1. bX3JyUJJ3QFnU
  2. T0fdQJnTtfeisTOjmKdFj19G2eWmXUYp8MYuPMzQbAXq79VR
  3. S0GFcqdT3DtX8Z
Product

methotrexate-loaded poly(lactic acid)-methacrylic acid copolymeric nanoparticles

Hydrodynamic diameter: ~ 239.5 nm

Medium: water

Support: none

References

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