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tenofovir loaded stearyl amine modified bolaamphiphilic nanovesicle

Based on

1 Patents
2014 Most recent source

Composition

1

HEPES buffer

Type Complex Compound
Formula
Role core
2

({[(2R)-l-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid

({[(2R)-l-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid (R)-9-(2-phosphonylmethoxypropyl)-adenine (R)-9-[2-(phosphonomethoxy)propyl]adenine tenofovir Viread® PMPA TNF TFV
Type Single Compound
Formula C9H14N5O4P
Role loaded material
3

bolaamphiphilic compound-lipid mixture

Type Complex Compound
Formula
Role layer
4

1-octadecylamine

octadecylamine stearylamine ODA
Type Single Compound
Formula C18H39N
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
tenofovir encapsulation

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • {2-[(5-{[(9E)-7-hydroxy-17-({11-[(9E)-12-hydroxy-13-({5-oxo-5-[2-(trimethylazaniumyl)ethoxy]pentanoyl}oxy)octadec-9-enamido]undecyl}carbamoyl)heptadec-9-en-6-yl]oxy}-5-oxopentanoyl)oxy]ethyl}trimethylazanium dichloride
  • cholesteryl hemisuccinate
  • cholesterol
See all (5)
  1. 6naWrNdRfs
Product

tenofovir loaded stearyl amine modified bolaamphiphilic nanovesicle

Hydrodynamic diameter: 57.36 - 59.38 nm

Medium: HEPES buffer

Support: none

References

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