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carboxyfluorescein loaded bolaamphiphilic nanovesicle

Based on

3 Patents
2014 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

phosphate buffer solution

PBS
Type Complex Compound
Formula
Role core
2

carboxyfluorescein

FAM CF
Type Single Compound
Formula C21H12O7
Role loaded material
3

bolaamphiphilic compound-lipid mixture

Type Complex Compound
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
carboxyfluorescein release dependent on acetylcholinesterase treatment

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Applications

Area Application Nanomaterial Variant Source
diagnostics

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Characterization

Method Nanomaterial Variant Source
cryo-electron microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
b.End3 immortalized mouse brain capillary endothelium cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • {2-[(5-{[(9E)-7-hydroxy-17-({11-[(9E)-12-hydroxy-13-({5-oxo-5-[2-(trimethylazaniumyl)ethoxy]pentanoyl}oxy)octadec-9-enamido]undecyl}carbamoyl)heptadec-9-en-6-yl]oxy}-5-oxopentanoyl)oxy]ethyl}trimethylazanium dichloride
  • cholesteryl hemisuccinate
  1. P2AYLT9t1e
  2. HGWEGUO
Product

carboxyfluorescein loaded bolaamphiphilic nanovesicle

Size: not specified

Medium: phosphate buffer solution

Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • {2-[(5-{[(9E)-7-hydroxy-17-({11-[(9E)-12-hydroxy-13-({5-oxo-5-[2-(trimethylazaniumyl)ethoxy]pentanoyl}oxy)octadec-9-enamido]undecyl}carbamoyl)heptadec-9-en-6-yl]oxy}-5-oxopentanoyl)oxy]ethyl}trimethylazanium dichloride
  • cholesteryl hemisuccinate
  1. TNSOxkNUlt
Product

carboxyfluorescein loaded bolaamphiphilic nanovesicle

Size: not specified

Medium: phosphate buffer solution

Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • {2-[(5-{[(9E)-7-hydroxy-17-({11-[(9E)-12-hydroxy-13-({5-oxo-5-[2-(trimethylazaniumyl)ethoxy]pentanoyl}oxy)octadec-9-enamido]undecyl}carbamoyl)heptadec-9-en-6-yl]oxy}-5-oxopentanoyl)oxy]ethyl}trimethylazanium dichloride
  • cholesteryl hemisuccinate
  1. pOCeIs562C
Product

carboxyfluorescein loaded bolaamphiphilic nanovesicle

Size: not specified

Medium: phosphate buffer solution

Support: none

References

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