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carboxyfluorescein loaded bolaamphiphilic nanovesicle

Based on

3 Patents
2014 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

phosphate buffer solution

PBS
Type Complex Compound
Formula
Role core
2

carboxyfluorescein

FAM CF
Type Single Compound
Formula C21H12O7
Role loaded material
3

bolaamphiphilic compound-lipid mixture

Type Complex Compound
Formula
Role layer

Properties

General physical and chemical properties

Property Value Source
carboxyfluorescein release dependent on acetylcholinesterase treatment

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Applications

Area Application Source
diagnostics

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Characterization

Method Source
cryo-electron microscopy

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Biological effects

Biological system Test details Source
b.End3 immortalized mouse brain capillary endothelium cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • {2-[(5-{[(9E)-7-hydroxy-17-({11-[(9E)-12-hydroxy-13-({5-oxo-5-[2-(trimethylazaniumyl)ethoxy]pentanoyl}oxy)octadec-9-enamido]undecyl}carbamoyl)heptadec-9-en-6-yl]oxy}-5-oxopentanoyl)oxy]ethyl}trimethylazanium dichloride
  • cholesteryl hemisuccinate
  1. Qqc79Fk2Kd
  2. Ghwx2hy
Product

carboxyfluorescein loaded bolaamphiphilic nanovesicle

Method 2

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • {2-[(5-{[(9E)-7-hydroxy-17-({11-[(9E)-12-hydroxy-13-({5-oxo-5-[2-(trimethylazaniumyl)ethoxy]pentanoyl}oxy)octadec-9-enamido]undecyl}carbamoyl)heptadec-9-en-6-yl]oxy}-5-oxopentanoyl)oxy]ethyl}trimethylazanium dichloride
  • cholesteryl hemisuccinate
  1. QuNBek7ddn
Product

carboxyfluorescein loaded bolaamphiphilic nanovesicle

Method 3

Type: Physical formation
Source:
Starting materials
  • cholesterol
  • {2-[(5-{[(9E)-7-hydroxy-17-({11-[(9E)-12-hydroxy-13-({5-oxo-5-[2-(trimethylazaniumyl)ethoxy]pentanoyl}oxy)octadec-9-enamido]undecyl}carbamoyl)heptadec-9-en-6-yl]oxy}-5-oxopentanoyl)oxy]ethyl}trimethylazanium dichloride
  • cholesteryl hemisuccinate
  1. jASRzZSULb
Product

carboxyfluorescein loaded bolaamphiphilic nanovesicle

References

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