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sorafenib-loaded folic acid-conjugated spermine-functionalized acetalated dextran nanoparticles

Based on

1 Articles
1 Patents
2017 Most recent source

Composition

1

folic acid-conjugated spermine-functionalized acetalated dextran

Type Biomolecule
Formula
Role carriers
2

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide

sorafenib SFN SOR SF
Type Single Compound
Formula C21H16ClF3N4O3
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug release dependent on pH

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Applications

Characterization

Method Nanomaterial Variant Source
transmission electron microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
breast cancer MDA-MB-231 cells

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • sorafenib tosylate
  • serum albumin
  1. Nnvrk5yF5M2ZDYaSNbCqova62f
  2. alqtZs67kfFnfEreqhs
Product

sorafenib-loaded folic acid-conjugated spermine-functionalized acetalated dextran nanoparticles

Size: not specified

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
  • folic acid-conjugated spermine-functionalized acetalated dextran
  1. r5w8NwYz5kI7RexJeH
  2. wshLeoBpDcmHiamzGG3GEJZ5lTAPg
Product

sorafenib-loaded folic acid-conjugated spermine-functionalized acetalated dextran nanoparticles

Diameter: ~ 130 - ~ 210 nm

Medium/Support: none

References

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