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20% DMAB-modified docetaxel-loaded PLGA-TPGS nanoparticles

Based on

1 Articles
2011 Most recent source

Composition

1

poly(lactide-co-glycolide)-D-α-tocopheryl polyethylene glycol 1,000 succinate random copolymer

PLGA-TPGS random copolymer
Type Polymer
Formula
Role carriers
2

1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}

docetaxel Taxotere Dtxl Doc Dtx
Type Single Compound
Formula C43H53NO14
Role loaded material
3

N-dodecyl-N,N-dimethyldodecan-1-aminium bromide

dodecyl-N,N-dimethyl-1-dodecanaminium bromide didodecyl dimethylammonium bromide didodecyldimethylammonium bromide dimethyldidodecylammonium bromide dilauryldimethylammonium bromide dDDdMABr DDAB DMAB
Type Single Compound
Formula C26H56BrN
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
biodegradability

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
MCF-7 cancer cell

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • N-dodecyl-N,N-dimethyldodecan-1-aminium bromide
  1. Z1j5zxFqKwivRTN9
Product

20% DMAB-modified docetaxel-loaded PLGA-TPGS nanoparticles

Size: 214.18 - 229.89 nm

Medium: water

Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • poly(lactide-co-glycolide)
  • 1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}
  1. CvBUWEZsVlBUeyhxhWDqecFjjn
Product

20% DMAB-modified docetaxel-loaded PLGA-TPGS nanoparticles

Size: 231.18 - 248.46 nm

Medium: water

Support: none

References

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