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IR-780 iodide-loaded methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone) micelles

Based on

1 Patents
2013 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

methoxy poly(ethylene glycol)-block-poly(ε-caprolactone)

mPEG5k-b-PCL10k mPEG-b-PCL
Type Polymer
Formula
Role carriers
2

near-infrared dye IR780 iodide

IR-780 iodide NIR dye IR780 IR780 iodide IR-780 IR780
Type Single Compound
Formula C36H44ClIN2
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
micelle-containing medium temperature

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Applications

Area Application Nanomaterial Variant Source
diagnostics

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Characterization

Method Nanomaterial Variant Source
dynamic light scattering

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Biological effects

Biological system Test details Nanomaterial Variant Source
female BALB/c athymic (nut/nut) mouse bearing HCT-116 human colon cancer xenograft

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • methoxy poly(ethylene glycol)-block-poly(ε-caprolactone)
  • near-infrared dye IR780 iodide
  1. miZSHhM
Product

IR-780 iodide-loaded methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone) micelles

Hydrodynamic diameter: ~ 187.9 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • methoxy poly(ethylene glycol)-block-poly(ε-caprolactone)
  • near-infrared dye IR780 iodide
  1. PxMpAm5
Product

IR-780 iodide-loaded methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone) micelles

Hydrodynamic diameter: ~ 172.2 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • methoxy poly(ethylene glycol)-block-poly(ε-caprolactone)
  • near-infrared dye IR780 iodide
  1. mzAtnBc
Product

IR-780 iodide-loaded methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone) micelles

Hydrodynamic diameter: ~ 165.7 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • methoxy poly(ethylene glycol)-block-poly(ε-caprolactone)
  • near-infrared dye IR780 iodide
  1. 1lGNcN3
Product

IR-780 iodide-loaded methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone) micelles

Hydrodynamic diameter: ~ 143.8 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • methoxy poly(ethylene glycol)-block-poly(ε-caprolactone)
  • near-infrared dye IR780 iodide
  1. oZsFxqv
Product

IR-780 iodide-loaded methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone) micelles

Hydrodynamic diameter: ~ 155.0 nm

Medium/Support: none

References

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