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Cremophor RH 40:Transcutol P-stabilized triacetin-dissolved etoricoxib oil-in-water nanoemulsion

Based on

1 Articles
2014 Most recent source

Composition

Image only illustrates the order and placement of components as described in literature.

1

1,2,3-triacetoxypropane

glycerin triacetate glycerol triacetate triacetin
Type Single Compound
Formula C9H14O6
Role core
2

2:1 Cremophor RH 40:Transcutol P mixture

Type Complex Compound
Formula
Role layer
3

water

Type Single Compound
Formula H2O
Role binder
4

etoricoxib

Type Single Compound
Formula C18H15ClN2O2S
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Brookfield viscosity

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
differential scanning calorimetry

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Biological effects

Biological system Test details Nanomaterial Variant Source
excised porcine abdominal skin

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • 1,2,3-triacetoxypropane
  • etoricoxib
Product

Cremophor RH 40:Transcutol P-stabilized triacetin-dissolved etoricoxib oil-in-water nanoemulsion

Droplet size: < 200 nm

Medium/Support: none

Method 2

Type: Physical formation
Source:
Starting materials
  • 1,2,3-triacetoxypropane
  • etoricoxib
Product

Cremophor RH 40:Transcutol P-stabilized triacetin-dissolved etoricoxib oil-in-water nanoemulsion

Droplet size: < 200 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • 1,2,3-triacetoxypropane
  • etoricoxib
Product

Cremophor RH 40:Transcutol P-stabilized triacetin-dissolved etoricoxib oil-in-water nanoemulsion

Droplet size: < 200 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • 1,2,3-triacetoxypropane
  • etoricoxib
Product

Cremophor RH 40:Transcutol P-stabilized triacetin-dissolved etoricoxib oil-in-water nanoemulsion

Droplet size: < 200 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • 1,2,3-triacetoxypropane
  • etoricoxib
Product

Cremophor RH 40:Transcutol P-stabilized triacetin-dissolved etoricoxib oil-in-water nanoemulsion

Droplet size: ~ 30 - ~ 100 nm

Medium/Support: none

References

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