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gemcitabine-loaded PLGA nanoparticles

Based on

1 Articles
2013 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role carriers
2

(4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)

2',2'-difluoro-2'-deoxycytidine 2',2'-difluorodeoxycytidine gemcitabine gemzar dFdC GEM Gem
Type Single Compound
Formula C9H11F2N3O4
Role loaded material

Properties

General physical and chemical properties

Property Value Source
drug entrapment efficiency

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Applications

Area Application Source
medicine/veterinary

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Characterization

Method Source
scanning electron microscopy

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Biological effects

Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • poly(lactic-co-glycolic acid)
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Product

gemcitabine-loaded PLGA nanoparticles

Method 2

Type: Physical formation
Source:
Starting materials
  • poly(lactic-co-glycolic acid)
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
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  4. 44jEf9YOni
Product

gemcitabine-loaded PLGA nanoparticles

Method 3

Type: Physical formation
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • poly(lactic-co-glycolic acid)
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  2. DiI
  3. 3FTk5
  4. TzqmPyORp8
Product

gemcitabine-loaded PLGA nanoparticles

Method 4

Type: Physical formation
Source:
Starting materials
  • poly(lactic-co-glycolic acid)
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
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  4. LoAdroGslO
Product

gemcitabine-loaded PLGA nanoparticles

Method 5

Type: Physical formation
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • poly(lactic-co-glycolic acid)
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  2. XtV
  3. 4nP3i
  4. fe0xj5mIIx
Product

gemcitabine-loaded PLGA nanoparticles

References

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