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gemcitabine-loaded PLGA nanoparticles

Based on

2 Articles
2013 Most recent source

Composition

1

poly(lactic-co-glycolic acid)

PLGA
Type Polymer
Formula
Role carriers
2

(4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)

2',2'-difluoro-2'-deoxycytidine 2',2'-difluorodeoxycytidine gemcitabine gemzar dFdC GEM Gem
Type Single Compound
Formula C9H11F2N3O4
Role loaded material

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
drug entrapment efficiency

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Method Nanomaterial Variant Source
scanning electron microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
human pancreatic carcinoma PANC-1 cells

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Preparation

Method 1

Type: Physical formation
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • poly(lactic-co-glycolic acid)
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Product

gemcitabine-loaded PLGA nanoparticles

Diameter: 210.5 - 221.5 nm

Medium/Support: none

Method 2

Type: Chemical synthesis
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • bovine serum albumin
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  2. klTjbI
Product

gemcitabine-loaded PLGA nanoparticles

Diameter: 107.5 - 111.9 nm

Medium/Support: none

Method 3

Type: Physical formation
Source:
Starting materials
  • poly(lactic-co-glycolic acid)
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
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  3. XXC8P
  4. eF2MFUQzJ2
Product

gemcitabine-loaded PLGA nanoparticles

Diameter: 168 - 188 nm

Medium/Support: none

Method 4

Type: Physical formation
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • poly(lactic-co-glycolic acid)
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  2. 6X4
  3. 8XOOQ
  4. wKcIuJlY6b
Product

gemcitabine-loaded PLGA nanoparticles

Diameter: 194.5 - 213.5 nm

Medium/Support: none

Method 5

Type: Physical formation
Source:
Starting materials
  • (4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]-1,2-dihydropyrimidin-2-one)
  • poly(lactic-co-glycolic acid)
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  2. UgT
  3. ixrr5
  4. iwz6ZLVToK
Product

gemcitabine-loaded PLGA nanoparticles

Diameter: 197.1 - 216.1 nm

Medium/Support: none

References

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