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siRNA/DOTAP-loaded PLGA-PEG nanoparticles

Based on

1 Articles
2013 Most recent source

Composition

1

mixture of substance based on (N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium/N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium/vascular endothelial growth factor small interfering RNA/vascular endothelial growth factor small interfering RNA)

Type Complex Compound
Formula
Role core
2

poly(ethylene glycol)-block-poly(lactic-co-glycolic acid) copolymer

PLGA-PEG
Type Polymer
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
medicine/veterinary

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Characterization

Biological effects

Biological system Test details Nanomaterial Variant Source
Nude female mouse with SKOV3 ovarian cancer

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • PLGA-PEG nanoparticles
  • mixture of substance based on (N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium/N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecenoyloxy]-1-propanaminium/vascular endothelial growth factor small interfering RNA/vascular endothelial growth factor small interfering RNA)
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  2. emZ
  3. MIP48VeDG6
  4. TKhO8Kq5
  5. WHX6q2
Product

siRNA/DOTAP-loaded PLGA-PEG nanoparticles

Diameter: 145.3 - 246.5 nm

Medium/Support: none

References

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