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folate-conjugated docetaxel/ketoconazole-loaded solid lipid nanoparticles

Based on

1 Articles
2013 Most recent source

Composition

1

mixture of substance based on (1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}/1,7β,10β-trihydroxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoate}/1-acetyl-4-[4-[[(2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine/1-acetyl-4-[4-[[(2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine)

Type Complex Compound
Formula
Role core
2

SL

Type Complex Compound
Formula
Role layer
3

stearic acid - folic acid conjugate

SA-FA
Type Complex Compound
Formula
Role layer

Properties

General physical and chemical properties

Property Value Nanomaterial Variant Source
Zeta potential

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Applications

Area Application Nanomaterial Variant Source
drug delivery

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Characterization

Method Nanomaterial Variant Source
transmission electron microscopy

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Biological effects

Biological system Test details Nanomaterial Variant Source
brain endothelial bEnd.3 cells ATCC CRL-2299

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Preparation

Method 1

Type: Chemical synthesis
Source:
Starting materials
  • 1-acetyl-4-[4-[[(2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
  • stearic acid - folic acid conjugate
  • 1-stearoyl-rac-glycerol
See all (6)
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  5. 8JcPeevqPYqBsK99j24
  6. sWvfVnT2UswVxDIc8inykSKZtb5UaYcVf5HoEIL
Product

folate-conjugated docetaxel/ketoconazole-loaded solid lipid nanoparticles

Diameter: 92 - 109.5 nm

Medium/Support: none

References

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